NetworkNewsBreaks – Xenon Pharmaceuticals, Inc. (NASDAQ: XENE) Shares Dive; XEN801 Disappoints in Phase 2 Clinical Trial

Shares of Xenon Pharmaceuticals (NASDAQ: XENE) are down 51% after the company reported topline efficacy results from the phase 2 clinical trial to evaluate the efficacy, safety, tolerability and systemic exposure of XEN801 for the treatment of moderate to severe facial acne. Trial results show that XEN801 did not demonstrate a statistically significant difference from vehicle placebo in its primary endpoint of the percent change in total lesion count from baseline to week 12. Results also show that XEN801 did not demonstrate statistical significance relative to key secondary efficacy endpoints. “Despite the good scientific and preclinical rationale to pursue SCD1 as a novel acne target, the topline clinical results do not support this hypothesis or the continued development of XEN801. While we are disappointed that XEN801 did not demonstrate efficacy in the treatment of acne, we have a broad, diversified pipeline of small molecule ion channel modulators based on targets with high human validation that we continue to advance,” president and CEO Dr. Simon Pimstone stated in the news release.

To view the full press release, visit: http://nnw.fm/w1h0O

About Xenon Pharmaceuticals Inc.

Xenon is a clinical-stage biopharmaceutical company discovering and developing a pipeline of differentiated therapeutics for orphan indications that it intends to commercialize on its own and for larger market indications that the company intends to partner with global pharmaceutical companies. Xenon has built a core enabling discovery platform, referred to as Extreme Genetics, for the discovery of validated drug targets by studying rare human diseases with extreme traits, including diseases caused by mutations in ion channels, known as channelopathies. Xenon’s Extreme Genetics platform has yielded the first approved gene therapy product in the European Union and a broad development pipeline and multiple pharmaceutical partnerships, including with Teva and Genentech. For more information, please visit www.xenon-pharma.com.

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